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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sapi</journal-id><journal-title-group><journal-title xml:lang="ru">Системный анализ и прикладная информатика</journal-title><trans-title-group xml:lang="en"><trans-title>«System analysis and applied information science»</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2309-4923</issn><issn pub-type="epub">2414-0481</issn><publisher><publisher-name>Belarusian National Technical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21122/2309-4923-2022-3-12-21</article-id><article-id custom-type="elpub" pub-id-type="custom">sapi-577</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Системный анализ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>System analysis</subject></subj-group></article-categories><title-group><article-title>Классификация  стадий  диабетической  ретинопатии  на основе нейронных сетей</article-title><trans-title-group xml:lang="en"><trans-title>Classification of diabetic retinopathy stages based on neural networks</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лукашевич</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lukashevich</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лукашевич Марина Михайловна, кандидат технических наук, доцент, докторант</p><p>Минск</p></bio><bio xml:lang="en"><p>PhD, Associate Professor, Postdoctoral Fellow</p><p>Minsk</p></bio><email xlink:type="simple">lukashevich@bsuir.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голуб</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Golub</surname><given-names>Y. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Голуб Юлия Игоревна, кандидат технических наук, доцент, старший научный сотрудник </p><p>Минск</p></bio><bio xml:lang="en"><p>PhD, Associate Professor, Senior Research Fellow</p><p>Minsk</p></bio><email xlink:type="simple">6423506@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Белорусский государственный университет информатики и радиоэлектроники</institution><country>Беларусь</country></aff><aff xml:lang="en"><institution>Belarusian State University of Informatics and Radioelectronics</institution><country>Belarus</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Объединенный институт проблем информатики Национальной академии наук Беларуси</institution><country>Беларусь</country></aff><aff xml:lang="en"><institution>United Institute of Informatics Problems, National Academy of Sciences of Belarus</institution><country>Belarus</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>12</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>12</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лукашевич М.М., Голуб Ю.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Лукашевич М.М., Голуб Ю.И.</copyright-holder><copyright-holder xml:lang="en">Lukashevich M.M., Golub Y.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://sapi.bntu.by/jour/article/view/577">https://sapi.bntu.by/jour/article/view/577</self-uri><abstract><p>Диабетическая ретинопатия является одним из основных побочных эффектов диабета, которая вызывает тяжелые последствия, вплоть до слепоты. Основной задачей является ранняя диагностика данного заболевания с целью своевременного и эффективного лечения. Диабетическая ретинопатия может быть обнаружена гораздо быстрее и более точно, если использовать методы машинного обучения для анализа изображений сетчатки глаза человека. Разработка методов и алгоритмов детекции и классификации данного заболевания, а также автоматизация этого процесса, являются актуальными задачами и экономически эффективным мероприятием.</p><p>В статье основное внимание уделено вопросу классификации стадий диабетической ретинопатии с помощью нейронных сетей на основе изображений сетчатки глаза человека. Oписана задача классификации стадий диабетической ретинопатии, а также предложено использование архитектуры глубоких нейронных сетей на основе VGG16 и VGG19 с добавление пользовательских слоёв. В результате проведенных экспериментальных исследований приведены рекомендации по выбору размера исходных изображений сетчатки глаза, а также этапу предварительной обработки (обрезке изображения).</p><p>Выполнено исследование используемого набора данных, в результате чего обучение моделей нейронных сетей и оценка результатов проводилась с учетом дисбаланса классов.</p></abstract><trans-abstract xml:lang="en"><p>Diabetic retinopathy is one of the main side effects of diabetes, which causes severe effects, including blindness. The main challenge is the early diagnosis of this disease for timely and effective treatment. Diabetic retinopathy can be detected much faster and more accurately by using machine learning methods for image analyzing of the human retina. The development of methods and algorithms for the detection and classification of this disease, the automation of this process are the actual and costeffective goals.</p><p>The article focuses on the classification of the stages of diabetic retinopathy using neural networks based on human retinal images. Classification problem of diabetic retinopathy stages is described.</p><p>The architecture of deep neural networks based on VGG16 and VGG19 with the addition of custom layers is proposed. Recommendations for the selection of the size of the initial retinal images and the preprocessing stage (cropping) are given As a result of the performed experimental research. Analysis of the dataset was performed. Neural network models were trained and results were evaluated with class imbalance taken into account.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>изображение</kwd><kwd>классификация</kwd><kwd>диабетическая ретинопатия</kwd><kwd>нейронные сети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>image</kwd><kwd>classification</kwd><kwd>diabetic retinopathy</kwd><kwd>neural networks</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bourne, R.R. Vision Loss Expert Group. Causes of vision loss worldwide, 1990-2010: a systematic analysis / R.R. Bourne, G.A. Stevens, R.A. White, J.L. Smith, S.R. Flaxman, H. Price, J.B. Jonas, J. Keeffe, J. Leasher, K. Naidoo, K. Pesudovs, S. Resnikoff, H.R. Taylor // Lancet Glob Health 2013. – T. 1, №6. C. 339-349. doi: 10.1016/S2214-109X(13)70113-X.</mixed-citation><mixed-citation xml:lang="en">Bourne, R.R. Vision Loss Expert Group. 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